To date, only 12 cases of mature cystic teratoma with sigmoid colon perforation have been reported in the literature.We report a rare case of mature cystic teratoma accompanied by sigmoid colon perforation treated using laparoscopicassisted surgery. A 25-year-old woman (gravida 2 para 0) was admitted to our hospital for evaluation of a 2-week history of fever. Magnetic resonance imaging revealed a large cyst filled with fat, as well as free air in the pelvis. Laboratory investigations showed evidence of significant inflammation. Therefore, we suspected mature cystic teratoma concomitant with bowel perforation.Colonoscopy confirmed a sigmoid colon perforation, and we performed laparoscopic-assisted surgery.Histopathological evaluation confirmed diagnosis of a mature cystic teratoma without malignant transformation.Malignancy should be considered in the differential diagnosis, and an appropriate operative procedure should be selected in patients with ovarian cysts concomitant with bowel perforation.

Endometriotic cysts often develop in the ovaries, while endometriotic nodules commonly develop in extra-ovarian sites. Herein, we report a rare case of an endometriotic cyst occurring in the mesosalpinx, and immunohistological reviews of its the pathogenesis. Magnetic resonance imaging of a 36-year-old multiparous female patient detected a 6 cm-large cyst in the right adnexal region. Likewise, a cystic tumor in the right mesosalpinx distant to the right fallopian tube and ovary, was detected via laparoscopy. On pathological examination, the inner surface of the cyst was lined with cuboidal epithelium and showed hemosiderin deposition and, thus, was diagnosed as an endometriotic cyst.Immunohistologically, it was positive for CD10 and vimentin, further supporting the diagnosis of endometriotic cyst. It was also positive for estrogen and progesterone receptors, indicative of a Müllerian-type epithelial character, and parts with positivity and negativity for the mesothelial marker calretinin were found. The calretinin-negative transition was considered to be due to a metaplastic process from peritoneal mesothelium to Müllerian-type epithelium. In conclusion, the coelomic metaplasia theory is possibly involved in the pathogenesis of endometriotic cysts located in the mesosalpinx.Detailed macroscopic findings via laparoscopy were also helpful in reaching this conclusion.

Introduction:No study in Japan has investigated alcohol's harm to others (AHTO).Therefore, this study aimed to reveal the situation of AHTO in Japan and examine the factors associated with it based on the relationship with the drinker. Methods: A cross-sectional population-based survey was performed in 2018 with 2121 men and 2507 women. Respondents were asked questions about factors such as verbal or physical aggression, being forced to drink alcohol, sexual harassment and their relationship with the drinker. Binomial logistic regression was performed to quantify the associations of AHTO with participants' socio-demographic status and drinking patterns. Results:The lifetime experience of AHTO was 24.7% for men and 19.3% for women. AHTO from the father and co-workers were the most common in and outside the home, respectively. The frequency of AHTO from the spouse or co-workers showed no significant difference for abstainers and drinkers. However, AHTO from the father was more commonly reported among drinkers and those with Alcohol Use Disorders Identification Test scores ≥8 points than abstainers. Of those who experienced AHTO, 24.5% of men and 27.6% of women, and 6.1% of men and 12.9% of women were profoundly affected by it in and outside the home, respectively. Discussion and Conclusions: One in five Japanese residents experienced AHTO in their life, and the characteristics associated with AHTO differed according to the affected individual's relationship with the drinker. Continued monitoring of AHTO and measures aimed at reducing alcohol-related harm that include AHTO should be promoted. K E Y W O R D S alcohol, family, gender, harm to others, workplace Key Points• Lifetime experience of alcohol's harm to others (AHTO) in Japan was 24.7% for men and 19.3% for women. • AHTO from spouses or co-workers was experienced by abstainers and drinkers.