The data from this large-scale report on clinical application of a commercially available noninvasive prenatal test suggest that the clinical performance of this single-nucleotide polymorphism-based noninvasive prenatal test in a mixed high- and low-risk population is consistent with performance in validation studies.

▼ Background:Smoking during pregnancy is a major risk factor for intrauterine growth retardation. The aim of the Thuringian SGA -(small-forgestational-age) -study was to evaluate the effects of maternal smoking during pregnancy on birth weight and length as well as postnatal growth dynamics and catch-up growth. Methods: Between 1992 and 2002 in all 2 447 liveborn children were assessed with birth weight (GG) < 10 th percentile and/or birth length (GL) < − 2.0 SDS. A questionnaire was sent to 383 parents of severe SGA children (GG and/or GL < − 2.5 SDS) to report weight and height of the children actually. 108 reports could analysed (mean age 8.0 ± 3.4 years of life). Results:The number of SGA babies in regard to all liveborn children decreased from 14.1 % to 9.4 % between 1992 and 2002. 14 % of SGA babies were born preterm. The mean nicotine abuse was 2 cigarettes per day (range 0-40). 17.6 % of the mothers of SGA babies were smoking, whereas in severe SGA 26.9 % of smokers was recorded. There is a inverse correlation of nicotine abuse with birth weight (r = − 0.09; p < 0.01) or birth length (r = − 0.08; p < 0.01). Catch-up growth did not exist in 30.6 % of the severe growth restricted children. The risk for short stature in later life was doubled in SGA children. Conclusions: Nicotine abuse during pregnancy is a risk factor for an SGA baby and could have long-lasting eff ects on growth dynamics during childhood with a lack of catch-up growth. Norm ab (r = − 0,05, p < 0,05). Während der Schwangerschaft rauchten 17,6 % der Mütter aus der SGA-Gruppe und 26,9 % der Mütter mit schwer retardierten Kindern. Es zeigten sich signifi kant niedrigere somatische Geburtsparameter bei den Neugeborenen rauchender Mütter im Abb. 1 Anteil retardierter Neugeborener bezogen auf alle Lebendgeburten, SGA -small for gestational age, Geburtsgewicht < 1. SDS (10. Perzentile), schwere SGA < 2,5 SDS (3. Perzentile). Abb. 4 aktuelle Körpergröße ehemaliger SGA-Kinder (n = 108). Dieses Dokument wurde zum persönlichen Gebrauch heruntergeladen. Vervielfältigung nur mit Zustimmung des Verlages.

A case report is presented herein of a 33-year-old woman with a history of congenital adrenal hyperplasia in 2 prior births. At 30 weeks of gestation, a scan of the fetal perineum demonstrated ambiguous genitalia which was confirmed at birth. This case demonstrates that when the fetal perineum is well visualized, the diagnosis of normal and abnormal genital development can be made sonographically. This can assist in perinatal/neonatal management, planning and in some cases, can also serve as an additional tool to monitor the success of prenatal steroid therapy of fetal congenital adrenal hyperplasia.