Notoamides O-R were isolated from a marine-derived Aspergillus sp. Notoamide O possesses a novel hemiacetal/hemiaminal ether functionality hitherto unknown among this family of prenylated indole alkaloids. The structure represents an unusual branch point for the oxidative modification of other members in the family of prenylated indole alkaloids in the biogenetic pathway.

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We estimated the protolith age and peak metamorphic temperature of the Yokokawagawa metamorphic rocks (YMR) east of the Itoigawa-Shizuoka Tectonic Line using detrital zircon U-Pb dating and Raman carbonaceous material geothermometry, respectively. U-Pb dating of a psammitic rock yielded a youngest age of ~100 Ma, which corresponds to the protolith age.Raman carbonaceous material geothermometry results for five pelitic rock samples give metamorphic temperatures of ~350-380 °C. The protolith age is consistent with those of the Sanbagawa metamorphic rocks (SMR), strongly indicating that the YMR are an extension of the SMR. The increase in peak temperature toward intrusive rocks along the eastern margin of the YMR may indicate that the relatively young ages yielded by previous K-Ar dating of the YMR reflect thermal resetting due to contact metamorphism.

Causal mediation analysis estimates causal effects by focusing on the mediators between cause and outcome. Multiple causally related mediators are often strongly correlated, making the estimation of causal effects difficult. In addition, recent years have seen a number of mediators compared to a sample size. In this paper, we propose a two-step estimation method based on sparse partial least squares regression and pathway lasso. The proposed method can identify the causal pathways among many candidate causal pathways. The effectiveness of the proposed method is shown by simulation studies and a real data analysis.