Wereport cases of amebiasis in 6 human immunodeficiency virus (HlV)-positive male patients. Five were confirmed homosexualswhile one was suspected. Three patients had liver abscess and 5 had colitis with duration of 10 days to months. The patients with liver abscess showeda lower incidence of abdominal pain but a higher incidence of concomitant diarrhea. Drainage therapy was effective for rapid afebrile results. Twoinvasive colitis cases died from perforation. This may have been due to delayed diagnosis. Invasive amebiasis is not commoneven in HIV-infected individuals. AmongJapanese homosexual men, however, it may cause symptomatic diseases. (Internal Medicine 40: 671-675, 2001)

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