Retro-aldol condensation of glucose occurred preferentially relative to dehydration and isomerization under low water density conditions in supercritical water, and glycolaldehyde was successfully produced in a rapid and selective manner without any catalyst. DJM This journal is

The fluorous support Hfb (see picture) enabled high‐yielding oligosaccharide syntheses in which the synthetic intermediates could be purified by simple fluorous–organic solvent extraction, and the reactions could be monitored spectroscopically and by TLC. Hfb was readily attached to the anomeric hydroxy group of a carbohydrate. The fluorous support could be removed in high yield, and was recyclable.

Three new fluorous supports for peptide synthesis, i.e., the trialkoxybenzhydryl-type (6), the Wang-type (7) and the tert-butyl-type support (8), were prepared. A bioactive peptide TRH was easily synthesized by an Fmoc strategy using the benzhydryl-type fluorous support with fluorous chemistry.

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