This paper describes the modeling of various emotional expressions and speaking styles in synthetic speech using HMM-based speech synthesis. We show two methods for modeling speaking styles and emotional expressions. In the first method called style-dependent modeling, each speaking style and emotional expression is modeled individually. In the second one called style-mixed modeling, each speaking style and emotional expression is treated as one of contexts as well as phonetic, prosodic, and linguistic features, and all speaking styles and emotional expressions are modeled simultaneously by using a single acoustic model. We chose four styles of read speechneutral, rough, joyful, and sadand compared the above two modeling methods using these styles. The results of subjective evaluation tests show that both modeling methods have almost the same accuracy, and that it is possible to synthesize speech with the speaking style and emotional expression similar to those of the target speech. In a test of classification of styles in synthesized speech, more than 80% of speech samples generated using both the models were judged to be similar to the target styles. We also show that the style-mixed modeling method gives fewer output and duration distributions than the styledependent modeling method.

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Iron(II) and cobalt(II) mononuclear metal complexes with tetrakis(2-pyridyl)methane have been synthesized and characterized. A gradual spin-crossover to the high-spin state above 300 K is observed in the cobalt(II) complex while the iron(II) complex exhibits no spin transition to the high-spin state between 5 and 400 K.

Fecal calprotectin level in ulcerative colitis patients is correlated with endoscopic findings. However, its association with various ulcerative colitis disease types has not been elucidated. In the present study, we investigated the correlation of fecal calprotectin level with endoscopic findings as compared to blood biomarkers according to ulcerative colitis disease type. Fecal calprotectin as well as the blood biomarkers: C reactive protein (CRP), white blood count (WBC), erythrocyte sedimentation rate (ESR), hemoglobin, platelet count (PLT), and serum albumin (Alb) were measured in patients who underwent a complete colonoscopy. Disease type was divided into proctitis, left sided colitis, and extensive colitis. Correlations of fecal calprotectin and blood biomarker levels with Mayo endoscopic subscore were analyzed. A total of 186 colonos copy examinations were performed in 124 patients with ulcerative colitis. Fecal calprotectin level showed a significant correlation with Mayo endoscopic subscore regardless of disease type (proctitis, r = 0.54, p<0.01; left sided colitis, r = 0.75, p<0.01; extensive colitis, r = 0.78, p<0.01), and clearly discriminated inactive (Mayo endo scopic subscore 0) from active stages (Mayo endoscopic subscore 1-3). On the other hand, none of the examined blood biomarkers showed a correlation with Mayo endoscopic subscore in the proctitis group, while weak correlations of several biomarkers (CRP, WBC, ESR, PLT and Alb) with Mayo endoscopic subscore were found in left sided colitis and extensive colitis cases. This is the first report to elucidate the capabilities of fecal calprotectin and blood biomarkers as endoscopic surrogate markers according to ulcerative colitis disease type.