The approved kit for S-p53Ab testing was found to be an effective tumor marker of colorectal cancer. The positive rate of S-p53Ab was significantly higher in patients with cancer involvement of the lymphoid tissues. The positive rate of S-p53Ab was higher than that of CEA and CA19-9 in patients with stage I colorectal cancer, suggesting that the S-p53Ab is a useful tumor marker for patients with early-stage disease.

Surgical site infections continue to be a common complication affecting surgical prognosis. Reactive oxygen species (ROS) are generated by ultrasound-irradiated titanium dioxide (TiO ) (UIT). Although excessive ROS production can cause cell damage, ROS at physiological levels mediate beneficial cellular responses, including angiogenesis. This study investigated whether UIT can promote healing of Escherichia coli-infected wounds. We used TiO and ultrasound irradiation using an ultrasonography machine at a frequency of 1.0 MHz and intensity of 0.4 W cm . These levels are not bactericidal in vitro; therefore, we could study the effect of UIT on E. coli survival without interference of ultrasound effects. The number of cluster of differentiation 31-positive blood vessels, which are indicative of angiogenesis, was decreased by bacterial infection, and increased at the wound edges in the UIT-treated infected wounds, suggesting upregulation of neovascularization by UIT. Although UIT treatment did not decrease E. coli survival in vivo, it promoted healing of the infected wounds as evidenced by a significant decrease in the wound area in the UIT-treated mice. Our findings demonstrate that UIT promotes wound healing in surgical site infections and suggest beneficial use of the UIT-based approach as a novel therapeutic method to treat infected surgical wounds. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2344-2351, 2017.

Adult intussusception is rare and most often associated with cancer. We report a case of intussuscepted sigmoid colon into the rectum protruding from the anus of a 47-year-old woman. The cause of the intussusception was sigmoid colon cancer. We removed the intussuscepted part of the sigmoid colon as well as the rectum and regional lymph nodes. The patient recovered uneventfully and there has been no evidence of recurrence of the cancer.

The frequency of anastomotic leakage was relatively low, and therefore the use of a linear stapler with pre-attached bioabsorbable PGA felt might reduce the risk of adverse events related to anastomosis, especially anastomotic leakage.

IgG4 関連疾患はさまざまな臓器に起こりうるが，多くは腺管臓器においてであり，心血管領域での報告は 少ない．今回われわれは IgG4 関連疾患による冠動脈周囲腫瘍の 1 例を経験したので報告する．症例は 69 歳 男性．胸部 CT 上，2 年前から増大し続ける，冠動脈周囲の腫瘍性病変にたいし，確定診断目的で開胸生検 術を行った．病理組織診断では線維性結合組織内に形質細胞とリンパ球の密な増生を認め，好酸球も認めら れた．全体的に線維化が目立ち，一部で肥厚した膠原線維をともなっていた．免疫染色では形質細胞の多く は IgG4 陽性であり，生検後測定した血漿 IgG4 濃度は 1,080 mg/dl と高値を示した．以上から IgG4 関連疾 患の冠動脈周囲腫瘍と診断した．心血管領域の IgG4 関連疾患は非常に稀であり，本症例は IgG4 関連疾患 による冠動脈周囲炎が腫瘍性病変を呈したものと思われた．日心外会誌 39 巻 4 号：230-233(2010) キーワード：IgG4 関連疾患，心臓腫瘍，冠動脈周囲腫瘍