An oxidosqualene cyclase from Arabidopsis thaliana makes arabidiol, a tricyclic triterpene reported with indeterminate side-chain stereochemistry. We established the full structure of arabidiol through chemical degradation, NOE experiments, and molecular modeling. By examining the mechanistic constraints that govern water addition in triterpene synthesis, we further show how the stereochemistry of hydroxylation can generally be deduced a priori, why deprotonation is more common than hydroxylation, and why cyclases that perform hydroxylation also generate olefinic byproducts.

The paper deals with the annual mandatory audit of closed joint stock companies, introduced in connection with the amendments made to the Civil Code. The introduction of mandatory audit for CJSCs determined the order of conducting the audit, the imposition of fines for failure to carry out statutory audit and the body that can administer the penalties.

-242 - Keywords: leader, gender stereotypes, management style, management, qualitative study, image of a woman, women's part to a corporate body, opinion.

One of the most topical problems in the field of healthcare is to solve the issues of an early diagnosis, timely prevention and effective treatment of cardiovascular diseases, which include arterial hypertension (the AH). Prevalence of EAH in the pediatric population in Russia amounts to 20 %. Despite the fact that the mechanisms of the disease were studied in detail, metabolic changes that led to its early development in teenagers were still not entirely clear. In the Clinic of FSBSI Scientific Center for Family Health Problems and Human

The article touched upon one aspect of actual problems concerning of the evaluating of passenger transport public network performance, namely the availability of the route network. In particular, the questions of the calculation of the public network density, range approach to stopping points, distances between stopping points and route coefficient, are touched