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Synthesis and Muscarinic Activity of 1,2,3,4-Tetrahydropyrimidine Derivatives.-Two series of tetrahydropyrimidine derivatives (VI) and (XII) related to the classical muscarinic agonists arecoline and milameline are synthesized and evaluated for their binding affinities for the cloned human muscarinic M 1 receptor. Some derivatives, especially the chlorobenzyl derivatives (VIe) and (XIIe), display binding affinities superior to that of milameline. -

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