The design features and the need to use a water-based solution make the task of ensuring trouble-free drilling of vertical wells non-trivial. This work is an example of an interdisciplinary approach to the analysis of the mechanisms of instability of the wellbore. Instability can be caused by a complex of reasons, in this case, standard geomechanical calculations are not enough to solve the problem. Engineering calculations and laboratory chemical studies are integrated into the process of geomechanical modeling. The recommendations developed in all three areas are interdependent and inseparable from each other. To achieve good results, it is necessary to comply with a set of measures at the same time. The key tasks of the project were: determination of drilling density, tripping the pipe conditions, parameters of the drilling fluid rheology, selection of a system for the best inhibition of clay swelling.