Layer systems composed of polydiacetylene lipids are known to undergo an irreversible colorimetric transition from blue to red upon exposure to an external trigger (e.g., heat, pH change, specific ligand−target interaction). These optical transitions offer numerous possibilities toward the development of molecule-based sensory materials. Polymerization of the diacetylene systems usually occurs only in a highly ordered phase as a topochemical reaction, if the diacetylenic units are packed in an optimal orientation. A novel system based on hydrazide derivatives of single-chain diacetylene lipids is described. These materials show an unusual aggregation and polymerization behavior in organic solution, in contrast to the parent carboxylic acids. In addition, these hydrazide lipids undergo an unprecedented reversible color change (blue/red) in polymerized vesicles when the pH of the surrounding aqueous medium is cycled between acidic and basic conditions. This unusual behavior is attributed to the unique hydrogen-bonding pattern of the hydrazide headgroup, and was investigated by 1H NMR, FTIR, UV−vis spectroscopy, and transmission electron microscopy. From the experimental data an ab initio computer model was developed to relate the observed colorimetric properties to intermolecular interactions.

Aim/objectives: To define a set of standards and validate them as a road map for future development of ADHD services in the UK. Methods:A multidisciplinary group of clinicians involved in the treatment of patients with ADHD met to define a set of appropriate consensus statements that would define the ideal structure and direction of improving service development in the UK. Forty statements were agreed, covering 10 topics, ranging from commissioning of ADHD services to optimisation of the care pathway. The statements were collated into a questionnaire and passed to other professionals at multidisciplinary meetings around the UK. The questionnaire data was analysed and scores produced for levels of agreement with each statement. Respondents were grouped into child & adolescent psychiatrists, paediatricians , nurses , trainees and other staff .Results: 122 respondents scored each statement on a questionnaire and levels of agreement were summated and analysed. Of 40 statements, only 4 scored less than 90% agreement (Table 1A), with all statements achieving greater than 74.9% agreement. All other 36 statements achieved greater than 90% agreement while six out these statements achieved greater than 99.1% agreement ( Table 1B) [ Table 1 and 2]Conclusions: All 40 statements therefore have broad support across the ADHD clinical and professional community and reflect strong agreement about what constitutes best practice in the management of ADHD and the direction for future development of services.

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