Purpose: To improve the hydrophobicity of diosmetin, the complex of diosmetin and lecithin was prepared and its physicochemical properties were characterized in this study. Methods: The complex of diosmetin and lecithin was prepared by solvent method. The physicochemical properties of the complex were investigated by ultraviolet-visible spectrometry (UV/Vis), infrared spectrometry (IR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and x-ray diffractometry (XRD). Results: Based on UV and IR analysis, there was no significant difference between the physical mixture and the complex while SEM showed that diosmetin in the complex did not present a crystal appearance but rather was dispersed in lecithin. DSC thermograms of the complex mainly showed that the presence of lecithin caused the characteristic endothermal peaks of diosmetin to disappear while x-diffractogramsshowed that the crystalline peaks of diosmetin was absent in the complex. Conclusion:The complex is held together by non-covalent-bond, and thus a new compound was not formed. Diosmetin in the complex is molecularly dispersed in the lecithin matrix.

Key indicators: single-crystal X-ray study; T = 294 K; mean (C-C) = 0.002 Å; R factor = 0.038; wR factor = 0.121; data-to-parameter ratio = 13.8.The title compound, C 22 H 28 N 2 O 6 , prepared by a condensation reaction between 3,4,5-trimethoxybenzaldehyde and ethylenediamine, acts as an important precursor for the synthesis of Schiff base complexes. The molecule is located on a centre of inversion with one half-molecule in the asymmetric unit. Both C N double bonds are in a trans configuration.

Key indicators: single-crystal X-ray study; T = 294 K; mean (C-C) = 0.007 Å; R factor = 0.050; wR factor = 0.140; data-to-parameter ratio = 14.0.In the title compound, [Cu(C 2 H 3 N) 2 (C 22 H 28 N 2 O 6 )]ClO 4 , the Cu atom is coordinated by two N atoms from one bidentate Schiff base ligand and two N atoms from two acetonitrile groups. The Cu atom adopts a tetrahedral geometry. The Cu-N(ligand) distances are 2.076 (3) and 2.089 (3) Å , and the Cu-N(acetonitrile) distances are 1.964 (4) and 1.975 (4) Å . Related literature

In this study, the inclusion complex of diosmetin with hydroxypropyl-β- -cyclodextrin (HP-β-CD) was prepared to improve the water solubility of diosmetin by the solvent method. The content of diosmetin in the complex was determined by UV. And the physicochemical properties of the complex were analyzed by ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC). The results showed that the physical phase of diosmetin had been changed. It was completely dispersed in HP-β-CD. HP-β-CD and diosmetin were combined by non-covalent bonds.

A total of 25 "heat-clearing and detoxifying" herbs used in Chinese medicine were investigated for their cytopathic effects on the growth of Newcastle Disease virus (NDV) in a chicken fibroblast cell line. The 5 herbs with the highest virus inhibitory effects were Herba agastaches, Flos chrysanthemi indici, Rhizoma anemarrhenae, Astragalus root and Baikal skullcap root and these were used in herbal formulations. Anti-NDV activities of 4 formulations were tested on the growth of NDV in the DF-1 fibroblast cell line. Formulation II, containing Baikal skullcap root, Astragalus root, Anemarrhena rhizome (1:1:2) and formulation IV containing Anemarrhena rhizome, Astragalus root and Flos chrysanthemi indici (1:1:1), which had strong anti-NDV activity in vitro, were used to determine the in vivo inhibitory effects of NDV-infection in chickens. After treatment with the two formulations serum IgY titres against NDV were improved, and morbidity was reduced in the NDV-infected chickens. The results suggest that the components in formulations II and IV acted synergistically to improve resistance to Newcastle disease and provide a basis for the developing an anti-NDV herbal medicine.