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IntroductionThe risk of drug-drug interactions (DDIs) is high in patients with chronic kidney disease (CKD) necessitating dose adjustments or the avoidance of drug combinations. This study aimed to evaluate DDIs among patients with CKD in the University of Nigeria Teaching Hospital (UNTH), Enugu, South-East Nigeria.MethodsThis study was a retrospective review of patients with CKD who received treatment at the nephrology unit of UNTH between January 2004 and December 2014. The drug-drug interactions (DDIs) of the prescribed drugs were classified using the RxList interaction checker. The IBM SPSS Version 21.0 was utilized for statistical analysis with P-value ≤ 0.05, considered statistically significant.ResultsA total of 749 DDIs were identified from the folders of the 169 patients with CKD that were eligible. Majority were above 50 years old and in stage 4 or 5 CKD. Furosemide, lisinopril and amlodipine were the most frequently prescribed drugs and had the greatest likelihood for nephrotoxicity. The number of medications and hypertension (as co-morbidity) were significant and independent predictors of DDIs among the patients. About 70% of the drug combinations required monitoring as they fell within the “significant category” of the RxList interaction checker. The most common interactions were between lisinopril and furosemide; furosemide and calcium carbonate; lisinopril and calcium carbonate.ConclusionThe prevalence of DDIs was high among the CKD patients. Prescribers and pharmacists in Nigerian hospitals may need to pay close attention to prescriptions of patients with CKD to identify, prevent and resolve undesirable DDIs.

BACKGROUND: Stigma affects the quality of life of the mentallyill, and health professionals are considered to be involved in possessing negative attitudes towards them. We evaluated the  prevalence of stigmatization among different health professionals in Nigerian hospitals.METHODS: This study was a descriptive, cross-sectional and comparative survey assessing attitudinal views of health professionals (doctors, pharmacists, and nurses) regarding mental illness in two hospitals in Eastern Nigeria. The survey utilized the 40-item Community Attitude to Mental Illness, CAMI-2 questionnaire. The prevalence and the factors that contribute to negative attitudes among this cohort were assessed. Statistical analysis using T-tests, ANOVA and Pearson Correlation were conducted.RESULTS: Attitudes to all the four constructs of the CAMI-2 werenon-stigmatizing. Stigmatizing attitudes were significantly higheramong pharmacists, doctors and then nurses (p<0.006). Health professionals who did not have contact with the mentally ill (p<0.0001), who were males (p=0.008) and had lower years of working experience (p=0.031) expressed significantly higher stigmatizing attitudes towards the mentally ill.Conclusions: Nigerian health professionals were largely non-stigmatizingtowards the mentally ill. However, being a pharmacist, of male gender, and working in a non-psychiatric hospital were associated with stigmatizing attitudes when they exist.KEYWORDS: Mental illness; Stigma; Health Professionals;Survey

Background: The increasing migration of health workers from low- and middle-income countries is an ongoing public health concern. This study evaluated the brain drain potential of pharmacy students in Nigeria.  Methods: This was a cross-sectional survey of final year pharmacy students from three Nigerian universities. Data collection was done via a 46-item self-administered questionnaire.     Results: There were 377 respondents. Reasons for potential emigration included better standard of living (n=334, 88.6%), access to advanced technology (n=330, 87.5%) and opportunity for professional development (n=341, 90.5%) in the destination countries. Respondents younger than 25 years were more likely to have a high emigration potential compared to those older (98.6% vs 84.6%, ꭓ2=10.816, p=0.029).     Conclusion: This study showed high emigration potential for the surveyed final year pharmacy students. This highlights the need for interventions that will promote retention and limit brain drain.