ijÿ ÷åðâîíîãî ïîëÿðèçîâàíîãî ñâ³òëà íà òî÷êó àêóïóíêòóðè Å-36 ï³äñèëþº ïðîòèáîëüîâèé åôåêò êîðâ³òèíó Íà ìîäåë³ ôîðìàë³íîâîãî òåñòó äîñë³äaeóâàëè ìîaeëèâ³ñòü ïîñèëåííÿ ïðîòèáîëüîâîãî åôåêòó êîðâ³òèíó ó ìèøåé ë³í³é Ñ57ÂL/6J ³ ÑBA/CaLac 䳺þ ÷åðâîíîãî ïîëÿðèçîâàíîãî ñâ³òëà (ÏÑ) íà òî÷êó àêóïóíêòóðè (ÒÀ) Å-36. Ðåºñòðóâàëè òðèâàë³ñòü áîëüîâî¿ ïîâåä³íêîâî¿ ðåàêö³¿ (âèëèçóâàííÿ óðàaeåíî¿ ê³íö³âêè), âèêëèêàíî¿ ³íºêö³ºþ 5%-ãî ðîç÷èíó ôîðìàë³íó â ñòîïó (0,25 ìêë, ï³äøê³ðíî) äî òà ï³ñëÿ ñèñòåìíîãî ââåäåííÿ êîðâ³òèíó (10 ìã/êã, âíóòð³øíüî÷åðåâèííî) àáî ñóêóïíîãî çàñòîñóâàííÿ êîðâ³òèíó ³ ÷åðâîíîãî ÏÑ (10-õâèëèííèé ñåàíñ â³äðàçó ï³ñëÿ ñòâîðåííÿ îñåðåäêó áîëþ). Óñòàíîâëåíî, ùî ï³ñëÿ àïë³êàö³¿ ÏÑ íà ïðîòèáîëüîâó ÒÀ Å-36 ó âñ³õ òâàðèí äîñòîâ³ðíî ï³äñèëþºòüñÿ ïðîòèáîëüîâèé åôåêò êîðâ³òèíó. Ó ìèøåé ë³í³¿ Ñ57ÂL/6J çàñòîñóâàííÿ îäíîãî êîðâ³ò³íó ïîñëàáëþâàëî áîëüîâó ðåàêö³þ íà 29,7 %, à ïðè ñóêóïíîìó âèêîðèñòàíí³ ÷åðâîíîãî ÏÑ ³ êîðâ³òèíó íà 53,1 %. Ìèø³ ë³í³¿ ÑBA/CaLac áóëè ìåíø ÷óòëèâ³ ÿê äî êîðâ³òèíó, òàê ³ äî ÏÑ. Êîðâ³òèí âèêëèêàâ ó íèõ ñêîðî÷åííÿ òðèâàëîñò³ áîëüîâî¿ ðåàêö³¿ íà 14 %, à ïðè ñïîëó÷åíí³ ç ÷åðâîíèì ÏÑ íà 32,4 %. Íåòðàâìàòè÷íèé, áåç ïîá³÷íèõ åôåêò³â ìåòîä 䳿 íèçüêî³íòåíñèâíèì ÏÑ ìîaeå áóòè ðåêîìåíäîâàíèé õâîðèì, ÿê³ ïðèéìàþòü êîðâ³òèí, äëÿ ïîñèëåííÿ éîãî åôåêòèâíîñò³. Êëþ÷îâ³ ñëîâà: êîðâ³òèí, ïîëÿðèçîâàíå ñâ³òëî, ôîðìàë³íîâèé òåñò, àíàëüãåç³ÿ, òî÷êà àêóïóíêòóðè Å-36.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.