Background: It is not clear what kind of drug is appropriate to heal forNSAIDs-induced enteropathy. Several reports showed the preventive effect of prostaglandin analogue or inducer using healthy subjects who took NSAIDs. However there was no report for healing effect and for patients. The aim of this study was to evaluate the healing effect of rebamipide in patients with NSAIDs-induced enteropathy.In addition, we evaluated for nutritional parameter. Methods: This study was conducted as a randomized, double-blinded, placebo-controlled, multicenter trial. Study protocol was approved by each hospital's ethical committees. Patients with LDA and/or NSAID more than 3 month were enrolled.Patients with enteropathy were divided into the placebo and the rebamipide groups.Rebamipide 100mg three times daily was administered during 4 weeks. Capsule endoscopies were performed at 0 and 4 week. The number of small intestinal ulcer and erosion were evaluated. Total protein was analyzed as nutritional parameters.

No abstract

No abstract

In order to consider characteristic chromosomal evolution, agamatoploidy in genus Carex, nuclear DNA content of metaphase plates in root tip of 50 cytologically stable strains belonging to 26 species of Carex collected in Japan was measured Feulgen cytophotometrically.Considerably large variation was observed in six species with rather high chromosome number. There was 7.7 times variation in DNA content among species analyzed in the present study. As assumed by earlier reports, it is presumed that C. siderosticta 4x and C. humilis were derived from C, siderosticta 2x and C. humilis ssp. nana, respectively.Among diploid species, 4.66 times but continuous variation was observed. There were no significant differences in nuclear DNA among four aneuploid of C. oxyandra and five of C. conica, respectively. Neither of five couples of strains, each belonging to a single species and having the same chromosome number but collected at different sites revealed any differences, indicating intraspecific aneuploid resulted from simple change of chromosome number. Three pairs of close relatives, C, f oliosissima vs. C. morrowii, C. paxii vs. C. nubigera and C. pumila vs. C. kobomugi, were similar to each other in DNA content. It is clear that the increase in chromosome number is accompanied by the decrease in nuclear DNA content; negative correlation and regression between DNA content and chromosome number were confirmed to be highly significant in 45 diploid species.Based on the evidence of various kinds of earlier investigrtions and the present study, it is suggested that species with many small chromosomes would be derived from species having small number of large chromosomes by means of fragmentation followed by slight reduction of DNA.

Conventional gene analysis, monosomic analysis and telocentric method of mapping were carried out with respect to a-amylase zymogram variations of germinating seed of hexaploid wheat. The gene for Band 1(Amy 6D1) was located on 6DL with the recombination value of 11.9±2.8(%) from the centromere. Its minor allele, Amy 6D1M and null allele, Amy 6D1° were also detected iii spelta duhamelianu*, and Prelude, respectively. The locus for Band 2 was polymorphic, there being two alleles, Amy 6A1 and Amy 6A1M, for Band 2 major and minor, respectively.The gene for Band 3, Amy 6B1, was on 6BL with the recombination value of 19.4±3.8(%) from the centromere. On this locus, there were two other alleles, Amy 6B14', and Amy 6B1° for Band 4' and absence of both Band 3 and 4', respectively.