respects with an authentic sample of 4-estrene-3,17-dione (4). The minor product was isolated in 5% yield and showed the following physical characteristics: mp 185-187 °C; NMR 0.93 (s, 3 H, C-18 Me), 5.

230ChemInform Abstract The phenethylamines (I) are coupled with the aldehydes (II), producing the regioisomeric isoquinoline derivatives (III) and (IV). The product ratio depends on the H+-concentration; at pH 7 a maximum of ortho cyclization, yielding (IV), is achieved. (1H-NMR-, MS-data).