Stagnation of peripheral blood ‰ow is the cause of various diseases. Changes in peripheral blood ‰ow after oral administration of Kampo medicines in mice with betamethasone-induced oketsu syndrome and normal mice were examined using a laser Doppler blood ‰ow meter. The Kampo medicines used were: Toki-shakuyaku-san; Kami-shoyosan; Keishi-bukuryo-gan; Daio-botanpi-to; Tokaku-joki-to; Goshuyu-to; and Hange-koboku-to. In the oketsu mice, blood ‰ow was improved by single-dose administration of Toki-shakuyaku-san, Kami-shoyo-san, Keishi-bukuryo-gan, Daio-botanpi-to, Tokaku-joki-to, and Goshuyu-to, but only Toki-shakuyaku-san increased blood ‰ow signiˆcantly in normal mice. In addition, blood ‰ow decreased after single-dose administration of Keishi-bukuryo-gan, Daio-botanpito, and Tokaku-joki-to in normal mice.