Background:Q-switched Nd:YAG laser, a melanin pigment-specific laser was used to treat melanocytic nevi in Indian patients.Objective:To assess the clinical response of nevi to Q-switched Nd:YAG laser of 1064 nm wavelength.Materials and Methods:Nineteen patients received an average of 2.57 treatments with Q-switched Nd:YAG laser of 1064 nm wavelength, repetition rate of 10 Hz, 10 nanoseconds pulse width, and spot size of 4 mm to 6 mm with a fluence ranging from 4 to 9.7 joules/cm2. The clinical end point of the laser treatment was brisk whitening. The response was assessed by using a global assessment score.Results:The clinical global assessment score showed excellent response in 8/19 patients and good response in 6/19 patients.Conclusion:The Q-switched Nd:YAG laser of 1064 nm wavelength resulted in significant improvement (lightening) of nevi.