To date, we could not determine a significant corneal damage in conjunction with the described complication. However, it is difficult to predict the long-term clinical course of our patient. Corneal decompensation as a result of possible endothelial toxicity of high-molecular weight sodium hyaluronate as well as spontaneous absorption seem possible.

We demonstrated the presence of the apoptosis-receptor system in hLECs. Furthermore, we demonstrated the possibility of the induction of key proteins of the apoptotic signalling cascade in these cells by the antimetabolic drug mitomycin C. This could have important implications on the strategies regarding both the prevention and the treatment of PCO after cataract surgery.

No abstract

Using profile program F-4 of the Octopus 201 computerized perimeter, retinal light sensitivity and threshold short-term fluctuations were studied in 15 eyes of 15 patients with glaucomatous field defects, with a resolution of 1.5 degrees. The scotomata were verified with programs 33 and 34 of the Octopus 201. Control profiles, either at identical locations in the healthy fellow eye or in areas showing no glaucomatous changes, were used to compare focal fluctuation in the vicinity of the scotoma. At the borders of the scotomata, between 20 degrees and 30 degrees eccentricity, a significant increase in short-term fluctuation of retinal sensitivity was found. This change in short-term fluctuation decreased with increasing distance from the field defect. Significantly greater short-term fluctuations were also detected in border-area measurements of scotomata located between 0 and 10 or 10 and 20 degrees of eccentricity.

Long-term regulation of IOP after trephining procedures was studied in 65 eyes with regard to the anatomical localization of the trephine hole. The observation period ranged between six and 39 months. The anatomical localization had no statistically significant influence on long-term pressure regulation after surgery, nor on the immediate postoperative situation. It was clinically impossible to localize the trephine within the trabecular area including Schlemm's canal with a high degree of accuracy. The use of larger-diameter trephines did not increase the probability of striking Schlemm's canal. With larger-diameter trephines the immediate effect on IOP was more pronounced, but the long-term IOP response was poorer. The absence of a filtering bleb or the development of a large filtering bleb was significantly more often associated with poor regulation of IOP in the long term. Where the trephine was positioned closer to the sclera, the incidence of choroidal detachment was higher. The diameter of the trephine had no effect on the occurrence of postoperatively flat chambers or choroidal detachments. Nor did the anatomical localization influence the incidence of postoperatively flat chambers.