In these preliminary trials, both lifestyle modification and OCs significantly reduce androgens and increase SHBG in obese adolescents with PCOS. Metformin, in combination with lifestyle modification and OC, reduces central adiposity, reduces total testosterone, and increases HDL, but does not enhance overall weight reduction.

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This article reviews the creation and evaluation of two instruments that measure ''treatment as usual'' (TAU) in a clinical research setting. The Service Provider and Medication Usage Grids were developed to assess children's past and current utilization of mental health services and medications. A pilot study revealed that compared to information gathered from other sources, these instruments provide an accurate method to assess, record, and track TAU in clinical studies. In addition, these instruments provide a clear and concise way to organize this information and do not require much time to administer. Limitations and directions for future research are discussed.

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