Microwave heating is becoming a widely accepted tool for synthetic chemists. While many reactions have been performed on a small scale using microwave heating, few have been further developed into larger‐scale syntheses. Here, a microwave‐promoted esterification reaction protocol is presented. The apparatus used allows for the removal of water generated during the course of the reaction and as a result the process can be driven toward completion. Reactions have been run on scales up to 3 mol.

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Aminocarboxylic acids (hydrazinocarboxylic acids) and esters Q 0440 Fast, Easy, Solvent-Free, Microwave-Promoted Michael Addition of Anilines to α,β-Unsaturated Alkenes: Synthesis of N-Aryl Functionalized β-Amino Esters and Acids. -(AMORE, K. M.; LEADBEATER*, N. E.; MILLER, T. A.; SCHMINK, J. R.; Tetrahedron Lett. 47 (2006) 48, 8583-8586; Dep. Chem., Univ. Conn., Storrs, CT 06269, USA; Eng.) -Mais 12-087