Graphical Abstract Highlights d METTL13 is the physiologic eEF1A lysine 55 dimethyltransferase d METTL13 dimethylation of eEF1A stimulates protein synthesis in cancer cells d The METTL13-eEF1A methylation axis fuels Ras-driven tumorigenesis in vivo d METTL13 depletion sensitizes cancer cells to PI3K and mTOR pathway inhibitors

EV-derived miRNAs from atherogenic macrophages, in particular miR-146a, may accelerate the development of atherosclerosis by decreasing cell migration and promoting macrophage entrapment in the vessel wall.