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Objective:Guggulu (Commiphora wightii [Arn.] Bhandari) is a well-known anti-hyperlipidaemic drug. Guggulsterones are active components of this drug which are responsible for this effect. The activity of Guggulu may depend upon its nature, fresh samples are recommended for their bṛhmaṇa (body mass increasing) effect; while lekhana (scarificant) effect is attributed to the old one. The comparative Anti-hyperlipidaemic activity of fresh and old samples has not been reported till date.Materials and Methods:Freshly collected and one year old samples of Guggulu were processed in gomūtra. Patients who satisfied inclusion criteria of Hyperlipidaemia were randomly distributed into two groups and the drug was administrated in a dose of 1 g with luke warm water twice a day for eight weeks.Results:Significant improvement was found in the symptoms of Medoroga and Lipid profile with treatment in both the groups. Fresh sample of Guggulu proved to have a better effect in lowering serum cholesterol (5.76%), triglyceride (17.17%), and very low density lipoprotein VLDL (18.36%) levels while old sample of Guggulu provided mild effect in lowering serum triglyceride (13.64%), VLDL (11.07%) and non-significant increase in serum HDL-cholesterol (0.94%). Old sample of Guggulu also provided significant decreases in body weight (7.69%) and BMI (7.82%).Conclusions:Old Guggulu showed better effect on body weight, BMI and cardinal symptoms along with significant lipid lowering effect whereas fresh Guggulu showed better result on lipid profile.

Introduction: Śodhana is a preliminary process that helps in eliminating possible physical or chemical blemishes from raw material and making them suitable for therapeutic application. Guggulu (Commiphora wightii (Arn) Bhandari) is a well-known herb in Āyurveda, which is gaining its attention in world market. Exudate of the plant is therapeutically active and need to process before it is converted into formulations. As a little data is available on standard manufacturing procedure of Guggulu Śodhana; the current attempt is planned to evaluate the same. Methods: Guggulu was procured from Gujarat state forest department corp. Ltd., Vadodara. Śodhana was done in 10 batches in Gomūtra. Organoleptic characters, loss on drying, ash value, acid insoluble ash, water soluble extractives, methanol soluble extractives, pH and volatile oil content, HPTLC, HPLC, FTIR, Heavy metal analysis and Microbial over load were carried out. Results: Average 80.56% yield was observed after Śodhana. Differences were found in physico-chemical, HPLC and FTIR analysis that show the impact of Śodhana procedure on Guggulu. Conclusion: The adopted method for Guggulu Śodhana can be considered as easy, convenient and standard procedure and the values of physicochemical parameters may be taken for quality assurance.

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