The use of polluted water bodies for recreation carries the threat of an outbreak of infectious diseases. A new method for determining the integral indicator of the occurrence of infectious diseases due to recreational water use is proposed. The cause of infectious disease can be not only swimming in water bodies, but also poor-quality food or drinking water, as well as soil pollution on the territory of beaches. Therefore, in the study of infectious diseases associated with recreational water use, it is proposed to calculate weighting factors separately for food products (Ff), drinking water of centralized water supply (Fdvc), drinking water of non-centralized water supply (Fdvd), surface water in places of mass recreation of people ( Fwr) and soil in the beach zone (Fsb) on the basis of research carried out by the bodies of the state sanitary and epidemiological service. Based on the data of state statistics by using a new method, an integral indicator of the occurrence of infectious diseases as a result of recreational water use in the city of Kharkiv was determined. The application of the proposed method will make it possible to make a scientifically based decision regarding the management of water resources and the protection of public health. The authors of the article conducted a study of the quality of surface water according to hydrochemical and bacteriological indicators in the summer of 2021 on 6 beaches of the city Kharkiv. On all beaches, there is a significant excess of the values of biogenic and bacteriological indicators, which creates a threat of infectious diseases. The risk values correspond to the 4th and 5th class of danger (high and very high impact on public health). The analysis of the evaluation of the weighting coefficients allows to determine the main causes of the development of infectious diseases in order to make scientifically based decisions on ensuring comfortable living conditions for the population. Identifying all possible sources of pollution, being aware of changes that may negatively affect water quality, and providing adequate information to the population are important preventive measures for public health protection. Keywords: public health, recreational water use, infectious disease, pollution sources, Kharkiv city.

Summary. Introduction The article is devoted to the achievements and prospects of the development of translational medicine at the international level, the state of development, problems and prospects in Ukraine, proposals for improving the system of innovations in health care in modern conditions of martial law. The purpose is to study the development of translational medicine and the prospects for implementing its principles in Ukraine. Materials and methods. To perform the task, an analytical review of publications in the electronic databases of medical and biological publications PubMed Medline of the US National Library of Medicine (NLM), Cochrane Database of Systematic Reviews was conducted. The results. The result of a systematic literature review of the state of translational medicine in Ukraine, which was carried out, is the conviction that the need to create new services and programs that ensure close cooperation between state, commercial and non-commercial organizations of our country, greater accessibility and transparency of new data for all is ripe. Researchers working in the field of broadcasts of inventions. The creation and development of databases with various information on a large number of patients opens wide opportunities for improving the quality of preclinical and clinical trials, and at the same time requires increasing their availability for researchers around the world. It is necessary to increase the use of the potential of social media and/or messengers for the introduction of modern achievements of translational medicine into the clinical practice of our country, the medical community should receive educational programs, recommendations and support infrastructure in social networks. Conclusions. In order to form an effective scientific and educational environment, it is necessary to create a national Institute of Pharmacy and Translational Medicine. It is necessary to create and implement in the educational pharmaceutical space of Ukraine an innovative educational program aimed at training specialists and research personnel of the new generation to work in various branches of the biopharmaceutical industry. It is expedient to create biological models of the use of drugs that allow testing of dose-response effects and to build pharmacokinetic models for specific environmental conditions, which will increase the predictive power of test results during its transition to the stage of clinical trials.

Introduction. Monkey pox is an anthropozoonous disease caused by orthopoxvirus, characterized by fever, general intoxication and skin rash, in some cases it can lead to fatal consequences; an infectious disease covered by international health regulations (IHR). The causative agent of the disease is classified as a biological agent - agent of a biological weapon. Most of the monkeypox cases associated with the 2022 outbreak are in the Western Hemisphere. Purpose: study of data on etiological, pathogenetic, epidemiological aspects, modern approaches to the diagnosis, treatment and prevention of monkeypox, the state of the problem in Ukraine and the world. Materials and methods: to perform the task, a review of publications was conducted in electronic databases of medical publications PubMed Medline of the US National Library of Medicine (NLM), Cochrane Database of Systematic Reviews, CDC (Centers for Disease Control and Prevention) website of the federal agency of the Ministry of Health USA. Results: The second generation ACAM2000 and third generation JYNNEOS™ monkeypox vaccines are currently available. Both vaccines are able to create immunity against monkeypox. Post-exposure vaccination can help prevent or reduce the severity of monkeypox. ACAM2000 is a single-dose vaccinia vaccine licensed by the FDA for the prevention of smallpox. Full immunity is achieved 4 weeks after vaccination. FDA expanded access to investigational protocol allows use of ACAM2000 for monkeypox immunization during an outbreak. The immunogenicity and protective efficacy of ACAM2000 is equivalent to that of the first generation Dryvax® smallpox vaccine. Smallpox vaccine virus is used as a live attenuated virus in the smallpox vaccine. Cases of encephalitis and Guillain-Barré syndrome following smallpox vaccination show that the incidence varies not only from place to place, but also from year to year in the same place. For the purposes of containment of the outbreak, prevention to reduce the risk of transmission from person to person, immediate detection of new cases and surveillance measures are necessary. Health care workers who provide care to patients with suspected or confirmed monkeypox who work with their specimens should use standard precautions to control infection. Specimens taken from animals or humans suspected of having monkeypox should be handled in equipped laboratories by trained personnel. According to WHO recommendations, samples taken from patients should be appropriately labeled, prepared for transportation using triple packaging. To prevent the further spread of monkeypox through the animal trade, captive animals potentially infected with smallpox must be isolated from other animals and quarantined for 30 days. Conclusions: 1.The monkeypox virus, which used to be endemic to certain regions of Africa, is now a global concern, with cases increasingly being reported in regions of the Western Hemisphere. 2. In connection with the fact that transmission from person to person most often occurs through airborne droplets or through direct contact with the mucous secretions of an infected person, social distancing and contact tracing are advisable. 3. In the last 6 months, cases of monkeypox have been confirmed among middle-aged people, which can be explained by the loss of cross-immunity from the smallpox vaccine. 4. The monkeypox virus multiplies in the cytoplasm and matures, creating primary viremia. Manifestations of a severe course of monkeypox are bronchopneumonia, respiratory distress syndrome, encephalitis, chorioretinal scars on the retina, etc. To minimize the risk of complications, it is advisable to provide timely treatment. 5. Medical organizations around the world are focused on understanding how cases of monkeypox are increasingly occurring in countries in the Western Hemisphere. 6. The study of etiotropic methods of treating monkey pox is promising.

Coronavirus disease can have a variety of clinical symptoms, ranged from asymptomatic to severe and even critical ones. To date, an information on the epidemiology, clinical features, prevention and treatment of this disease is insufficient, which requires a further study of the problem. To personalize the treatment, it is important to determine the leading clinical and laboratory predictors to forecast the severity of COVID−19. The algorithm of examination of a patient includes the assessment of all complaints, data of the anamnesis of the disease, epidemiological anamnesis. The combination of clinical examination to determine the severity of the patient's condition includes physical examination, the one of diagnostic material using methods of nucleic acid amplification and / or enzyme−linked immunosorbent assay, pulse oximetry. Laboratory, etiological diagnostics, tests and antibodies play an important role. In case of hospitalization of the patients with moderate, severe and extremely severe infection, clinical studies are required such as: general (clinical) and biochemical blood test, coagulogram, diagnosis of disseminated intravascular coagulation syndrome, as well as identification of risk factors. Instrumental and radiological diagnostics include: pulse oximetry with measurement of SpO2 level, computed tomography and ultrasound examination of lungs and pleural cavities, electrocardiography. Comprehensive evaluation of clinical and laboratory data of patients allows to determine a clinically confirmed COVID−19, to route the patient and to start complex therapy in time. A promising direction is the introduction of the method of quantitative diagnostics by polymerase chain reaction on SARS−CoV−2 RNA in the activity of laboratories of Ukraine, which will help to individualize the degree of viral load in patients, improve treatment control. Key words: COVID−19, predictors of course severity, methods of laboratory diagnostics, quantitative polymerase chain reaction.

Currently, the epidemic situation regarding the incidence of coronavirus infection COVID−19 in Ukraine continues to be tense. In order to in−depth study of the problem of clinical features, treatment and prevention of this disease, as well as the development of a mathematical model for predicting the severity of its course, 30 patients aged 18 to 85 years were examined. Among the patients there were young and middle−aged people as well as elderly patients with chronic diseases, namely obesity, hypertension, diabetes. The diagnosis of coronavirus infection was confirmed in all the patients by molecular genetic method, i.e. SARS−CoV−2 RNA was isolated, and in 10 patients − IgM + IgG to SARS was determined by immunochromatographic analysis. With COVID−19, young and middle−aged patients have a fairly mild course with a decrease in platelet count by 7 %, erythrocyte sedimentation rate by 48 %, prothrombin by 14 % and D−dimer by 31 %. The construction of regression equations based on trend lines revealed that in elderly patients after treatment there was a further decrease in the level of D−dimer (20 %), an increase in platelet count (30 %), a decrease in white blood cell count (26 %), neutrophils (38 %), increase in lymphocyte levels by 3 times, decrease in erythrocyte sedimentation rate (by 10 %) and prothrombin parameters (by 15 %). Based on cluster and regression analysis, coefficients were calculated for each prognostic function. It was found that the linear dependence and statistically significant effect on the course of COVID−19 in all patients have leukocytes, erythrocyte sedimentation rate and D−dimer. In order to prevent the spread of coronavirus infection in Ukraine COVID−19 in this March, quarantine was introduced throughout the country, which is being extended to this day. There is no doubt about the importance of recommendations for improving anti−epidemic measures to prevent coronavirus infection throughout Ukraine. Key words: coronavirus infection, COVID−19, clinical blood counts, disease prognosis, anti−epidemic measures in Ukraine.