No abstract

It is known, that long decrease in gastric secretion leads to the development of hypergastrinemia, dysbiosis and to pathological changes in digestive organs. Very important there is a search of ways to correction of these undesirable consequences. Long-term usage of omeprazole leads to metabolic disorders in periodontium tissues and salivary glands, such as development of NO-ergic system disbalance and activation of freeradical oxidation, that are positively corrected by multiprobiotic of new generation "Symbiter acidophilic".

Âïëèâ ìóëüòèïðîá³îòèêà ñèìá³òåðó àöèäîô³ëüíîãî íà ïàòîëîã³÷í³ çì³íè ó ê³ñòêîâ³é òêàíèí³ ïàðîäîíòà ïðè ã³ïîàöèäíîñò³ Íà ìîäåë³ îìåïðàçîë³íäóêîâàíîãî ã³ïîàöèäèòåòó îáãðóíòîâàíî åêñïåðèìåíòàëüíó êîðåêö³þ ïàòîëîã³÷íèõ çì³í ó ê³ñòêîâ³é òêàíèí³ ïàðîäîíòà ìóëüòèïðîá³îòèêîì ñèìá³òåðîì. Äîâåäåíî, ùî éîãî âèêîðèñòàííÿ â óìîâàõ òðèâàëî¿ ã³ïîàöèäíîñò³ øëóíêîâîãî ñîêó ñïðèÿº ïîïåðåäaeåííþ êàòàáîë³çìó êîëàãåíîâèõ ³ íåêîëàãåíîâèõ á³ëê³â îðãàí³÷íîãî ìàòðèêñó ê³ñòîê íèaeí³õ ùåëåï ³ íîðìàë³çàö³¿ NO-åðã³÷íî¿ ñèñòåìè.

Under conditions of omeprazole-induced hypergastrinemia the activity of NOS and the concentration of NO 2 , the end product of metabolism of nitric oxide were studied in salivary glands of rats. We detected an increase in NOS activity, reaching a maximum (7,61±0,39 ìmol [NO 2 ]/(g*min) at 14th day of the experiment. At 28th day following omeprazole introduction its activity was 5,76±0,25 ìmol [NO 2 ]/(g*min).