It is still not fully understood how to predict the future prognosis of patients at the diagnosis coronavirus disease 2019 (COVID-19) due to the wide clinical range of the disease. We aimed to evaluate whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load could predict the clinical course of pediatric patients. This study was conducted retrospectively with medical records of pediatric patients who were tested for SARS-CoV2 between April 12 and October 25, 2020 in the

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We analyzed the performance parameters of the traditional and the reverse algorithms to find out which one is more convenient for serodiagnosis of syphilis. In total, 4789 serum samples were obtained in a cross-sectional study. Venereal Disease Research Laboratory (VDRL), Treponema pallidum Haemagglutination Assay (TPHA) and Chemiluminescent Microparticle Immunoassay (CMIA) tests were performed for every serum sample. In case of discordance between results, the TPHA was applied as a second treponemal test. Overall, 207 patients were serodiagnosed with syphilis. Among 4789 subjects tested, 125 (2.6%) and 206 (4.3%) were positive using the traditional algorithm and the reverse algorithm, respectively.The missed diagnosis rate of the traditional algorithm was 42.5%. The reverse algorithm had higher sensitivity than the traditional algorithm. Sensitivity levels of the traditional and the reverse algorithms were 57.49% and 99.85% respectively. The false positivity of the reverse algorithms was 0.02%.

Sağlıklı yetişkinlerin bağırsak ve vajinal florasında kolonize olabilen Grup B streptokoklar (GBS), özellikle yenidoğanlarda menenjit ve sepsis, gebeler ve altta yatan hastalığı olan erişkinlerde yumuşak doku enfeksiyonları ve idrar yolu enfeksiyonlarına neden olmaktadır. GBS enfeksiyonlarının tedavisinde ilk tercih penisilinlerdir. Ancak, son zamanlarda bildirilen azalmış penisilin duyarlılığı, alternatif ajanlara karşı artan direnç oranları ve penisilin allerjisi olan hastalar nedeniyle antibiyotik duyarlılıklarının bilinmesi tedaviye yön vermek açısından önemlidir. Bu çalışmada, laboratuvarımızda izole edilen GBS izolatlarının antibiyotik duyarlılıklarının değerlendirilmesi amaçlanmıştır.

When treponemal chemiluminescent microparticle immunoassay signal-to-cutoff ratio is ≥10.4, there is no need for confirmatory testing. This approach obviates the need for secondary treponemal testing in about 71% of the screening-reactive samples.