Stigmatizing attitudes and behaviors of the society can be associated with avoidance of treatment-seeking behaviors and reduced quality of life for the individual with mental illness. Among these problems, individuals with mental impairment are exposed to unfair behavior in the criminal justice system, restrictions on social facilities, and most importantly, reduced their roles in their life and community participation. Although researches have gone far to understand the impact of the disease, it has only recently begun to explain stigma in mental illness. Much yet needs to be done to fully understand the breadth and scope of prejudice against people with mental illness. Therefore, this chapter presents the stigmatization and its historical development and types and stigma in mental health and obsessive-compulsive disorders to provide a brief overview of issues in the area. Moreover, this chapter presents the occupational therapy interventions in stigma both in adults and children with obsessive compulsive disorder.