: Multiple studies on the pathomechanisms of depressive disorder and antidepressants have been reported. However, literature involving scientometric analysis of depressive disorder is sparse. Here, we use scientometric analysis and a historical review to highlight recent research on depression. We use the former to examine research on depressive disorders from 1998 to 2018. The latter is used to identify the most frequent keywords in keyword analysis, as well as explore hotspots and depression trends. Scientometric analysis uncovered field distribution, knowledge structure, research topic evolution, and topics emergence as main explorations in depressive disorder. Induction factor, comorbidity, pathogenesis, therapy and animal models of depression help illustrate occurrence, development and treatment of depressive disorder. Scientometric analysis found 231,270 research papers on depression, a 4-fold increase over the last 20 years. These findings offer a vigorous roadmap for further studies in this field.

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Background: Coronavirus disease 2019 (COVID-19) is currently rampant all over the world, resulting in unpredictable harm to humans. High blood levels of cytokines and chemokines have been marked in patients with COVID-19 infection, leading to cytokine storm syndrome. Cytokine storm, a violent inflammatory immune response, reveals the devastating effect of immune dysregulation and the critical role of an effective host immune response. Methods: Scientometric analysis summarizes the literature related to cytokine storm in recent decades and provides a valuable and timely approach to track the development of new trends. In this review, the pathogenesis and treatment of diseases associated with cytokine storm are summarized comprehensively on the basis of scientometric analysis. Results: Field distribution, knowledge structure, and research topic evolution correlated with cytokine storm are revealed, and the occurrence, development, and treatment of disease relevant to cytokine storm are illustrated. Conclusion: Cytokine storm can be induced by pathogens and iatrogenic causes, and can also occur in the context of autoimmune diseases and monogenic diseases as well. These reveal the multidisciplinary nature of cytokine storm and remind the complexity of the pathophysiological features, clinical presentation and management. Overall, this scientometric study provides a macroscopic presentation and further direction for researchers who focus on cytokine storms.