No abstract

We present our experience of using transvaginal three/four-dimensional (3D/4D) color Doppler with glass-body rendering mode and spatiotemporal image correlation (STIC) software to construct an image of persistent truncus arteriosus in the first trimester of pregnancy. There have been numerous reports on the antenatal diagnosis of truncus arteriosus using two-dimensional (2D) grayscale echocardiography, color Doppler and multiplanar display in 3D/4D ultrasound 1 -3 ; however, to the best of our knowledge, this is the first report on the antenatal diagnosis of truncus arteriosus using transvaginal Figure 1 Transvaginal two-dimensional echocardiography (a) and color Doppler ultrasound (b) of the fetal heart at 12 + 6 weeks of gestation, identifying truncus arteriosus (TA). A ventricular septal defect (VSD) is seen between the left (LV) and right (RV) ventricles. A single arterial trunk overrides the defect and divides into the aorta (Ao) and pulmonary artery (PA). Blood flow through the VSD, TA and its two divisions was observed. DAo, descending aorta; Sp, spine.Correspondence to: Dr T. Hata, Department of Perinatology and Gynecology, Kagawa University Graduate School of Medicine, 1750-1 Ikenobe, Miki, Kagawa 761-0739, Japan (e-mail: toshi28@med.kagawa-u.ac.jp) 3D/4D color Doppler with glass-body rendering mode and STIC.A 37-year-old pregnant Japanese woman, gravida 8, para 2, was referred to our ultrasound clinic at 12 + 6 weeks of gestation because of suspected fetal hydrops and omphalocele. Transvaginal 2D sonography showed a single live fetus with biometry consistent with gestational age. A cystic hygroma was seen extending from the occipital part of the fetal head to the fetal back, associated with a giant omphalocele containing the liver, stomach and intestines. Detailed cardiac examination revealed

There was a strong correlation between the cytocidal effect of nedaplatin and DNA crosslink formation. The cytocidal effect and DNA crosslinking in vitro depended on the exposure conditions used to define the AUC. Therefore, a new pharmacokinetic-pharmacodynamic model for nedaplatin must be constructed to investigate the most effective administration procedure in vivo.

No abstract

11,13,15‐Triazasteroidal skeleton with an alkyl group in the D‐ring was synthesized and it was screened for antidepressive activity. Compounds VIIId and XIIa exhibited antireserpine action.