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Background-In Sushrut Samhita a total of 67 variety of Keeta (insects) under 4 groups are being de-scribed. Most of the bites are not very harmful but sometimes poisonous bites can cause complications i.e. anaphylactic shock. Among these, Makshika (honeybee) is the subject of concern. In these stings, Lepa is useful mode of treatment. Aim and Objectives-Experimentally study of the effect of Mukta Lepa in Hon-eybee sting (Keeta Visha). To study the anti-inflammatory effect of Mukta Lepa due to Honeybee sting (Keeta Visha) in Albino Mice. Material & Methods- This study was carried out in albino mice categorized into three groups- control, standard drug and test drug for comparative evaluation. The control group received nothing, standard drug was beta cyclic ointment and test drug was MuktaPishti Lepa. The study was an acute toxicity study. The mice were subjected to honeybee (Apiscerenaindica) stings and the sting areas were given an application of test and standard drugs. Results were evaluated after a period of 7 days on the basis of redness, edema. Result-As per observation data, it is proved that Mukta Lepa is more effective as Standard drug hence it can be useful in Honeybee sting. It helps in reducing edema due to Honeybee sting. Conclusion- From this study it is proved that Mukta Lepa helps in wound healing. From the detailed pre-clinical study and obser-vational analysis, it is concluded that Mukta Lepa is effective and can be used in Honeybee sting.