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Highly sensitive biosensing of concanavalin A (Con A) has been developed based on the attenuation of FRET efficiency between amine-terminated quantum dots and mannose-stabilized Au nanoparticles in the presence of Con A, which inhibits the H-bonding formation of the QDs-AuNPs assembly, thereby causing the fluorescence recovery.Scheme 1 Schematic illustration of (A) FRET between amine-terminated QDs and mannose-stabilized AuNPs, and (B) Con A-induced attenuation of FRET.

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