Anisotropic Janus particles composed of biocompatible polymers have been gaining considerable interest for biomedical applications. Here, the fabrication of hybrid Janus particles via a single‐step solvent emulsion technique, potentially for theranostic purposes, is shown. Through this technique, the selective encapsulation of therapeutic and diagnostic agents is streamlined into different “faces” of the Janus structure. This facile technique is used to seamlessly fabricate polymeric‐based hybrid Janus particles for theranostic applications with little complexity.