Highlights
Specific knockout of Stat3 in osteocytes suppresses loading induced bone formation.
Stat3 deficiency in osteocytes decreases the material properties of femur.
Stat3 inhibitor causes Reactive Oxidative Species (ROS) accumulation in MLO-Y4 osteocytes.
Stat3 inhibitor blocked ATP-induced intracellular calcium influx into MLO-Y4 osteocytes.
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