Few studies have examined the practices of prescribing psychologists, and the extant literature suffers from small sample sizes due to the nature of the profession. The current study was based on data from 43 prescribing psychologists, the largest sample of prescribing psychologists examined to date. It was found that prescribing psychology is distinctive from both traditional psychological and psychiatric practice. Prescribing psychologists tend to work in multiple settings. Although respondents espoused a preference for combination therapy, monotherapy-whether medication or psychotherapy-remains the dominant option. Prescribing psychologists reported minimal interaction with pharmaceutical drug representatives. It is also prescribing psychologists' sense that nonprescribers in their community experience them in positive ways. Future studies should further address patient treatment themes within this practice, as well as looking into changes in interactions with pharmaceutical representatives. Public Significance StatementFive states are now awarding prescriptive authority to appropriately trained psychologists, which has the potential to change mental health practices in those states markedly. This study is the largest to date on the practices and activities of prescribing psychologists, and examines issues such as patient demographics, job duties, relations with nonprescribing psychologists, and interactions with pharmaceutical representatives.