We determined the mRNA levels ofc-jun and c-los in the liver of C3H-H-2* jvs mice. Both were higher injvs mice than in normal mice. The level of c-jun mRNA irxcreased gradually after birth, but in the control mice there was almost no change. In addition, ~-fetoprotein and aldolase A mRNA levels were also higher than in normal littermates. These results suggest that the pattern of the gene expression in jv~ mice partly resembles the one that occurs in undifferentiated hepatoeytes and/or hepatoccllular carcinoma.

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