A simple dipeptide, (S)-phenylglycyl-(R)-phenylglycine (S,R-1), formed inclusion compounds with a small amide such as formamide, acetamide, N,N-dimethylformamide (DMF), or N,N-dimethylacetamide. By single-crystal X-ray analysis, the inclusion compounds were shown to have a wavy layer structure. The molecules of S,R-1 are arranged in parallel via ionic pairing of the carboxyl and amino groups to construct the wavy layers. The guest molecules were accommodated in a channel cavity between the layers by means of hydrogen bonding with (+)NH(3) of S,R-1. The cavity is surrounded by the phenyl groups of S,R-1 that conformationally rotate so as to make the cavity size fit the guest amide.

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Inclusion compounds O 0400Inclusion Compounds of L,D-Dipeptide with Small Sulfoxides: Flexible Sheet Structure of (S)-Phenylglycyl-(R)-phenylglycine. -(AKAZOME*, M.; HIRABAYASHI, A.; SENDA, K.; OGURA, K.; Tetrahedron 63 (2007) 40, 9933-9938; Dep. Appl. Chem. Biotechnol., Fac. Eng., Chiba Univ., Inage, Chiba 263, Japan; Eng.) -Nuesgen 51-058