No abstract

-Anesthesia is used for pain control and is necessary in toxicological studies. In this study, we examined the effects of anesthesia on gene expression profiles caused by different types of anesthesia. To elucidate the effects of anesthesia on gene expression profiles, DNA microarray analysis was performed with CO 2 -O 2 anesthesia and isoflurane anesthesia, and gene expression profiles in the liver were analyzed. Consequently, a total of 209 probes out of 61,573 showed higher or lower expression levels in the isoflurane anesthesia group compared with CO 2 -O 2 anesthesia. This is less than 0.34% of all probes, indicating that the effects of different types of anesthesia on gene expression profiles are limited. However, careful consideration should be taken in the cases of handling the disturbed genes using DNA microarray, especially in case of research on glutathione-related pathway under isoflurane anesthesia.

This paper considers the problem of expanding a language class that can be proven by a noninteractive zero-knowledge proof system (NIZK) in a black-box manner in the common reference string model. Namely, given NIZKs for two languages, L 0 and L 1 , can we construct an NIZK for L 0 ∨ L 1 in a black-box manner? NIZKs for disjunctive languages have a large number of applications, such as electronic voting. Therefore, such a black-box construction may enable the efficient constructions of such applications. However, Abe et al. (PKC 2020) showed that this is impossible if the two given NIZKs are simulation-sound. In this paper, we prove that it is also impossible if the two given NIZKs are constructed by the commit-andprove methodology that is typically used in many cryptographic protocols, including NIZKs. This result suggests that if we want to augment the capability of NIZKs in terms of the languages they can prove, we should rely on certain properties or structures of the underlying NIZKs, such as algebraic structures.

No abstract