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PURPOSE:This study examined the changes in the blood fatigue variables caused by isokinetic and isotonic exercise training. METHODS:Ten healthy adult males with at least one year of athletic experience participated. The participants performed the isokinetic circuit exercise program first, followed by an isotonic circuit exercise program. A two-hour break was allowed between the isokinetic circuit exercise program and the isotonic circuit exercise program. The circuit exercise program consisted of four items (Squat, Deadlift, Shoulder press, and Bench press). The blood samples were analyzed for the LDH, CPK, and Cortisol levels. RESULTS: The LDH level in the isokinetic group was significantly different from the isotonic group. In particular, the change in LDH level in the isokinetic group was 33.30% lower than that of the isotonic group. The serum CPK level of the isokinetic group showed a 10.03% lower decrease than the isotonic group, but the difference was not significant. The Cortisol level was relatively unchanged in the isotonic group, †Corresponding Author : Kyoung Kim