A series of novel J147 derivatives were synthesized, and their inhibitory activities against β-amyloid (Aβ) aggregation and toxicity were evaluated by using the oligomer-specific antibody assay, the thioflavin-T fluorescence assay, and a cell viability assay in the transformed SH-SY5Y cell culture. Among the synthesized J147 derivatives, 3j with a 2,2-dicyanovinyl substituent showed the most potent inhibitory activity against Aβ42 oligomerization (IC50 = 17.3 μM) and Aβ42 fibrillization (IC50 = 10.5 μM), and disassembled the preformed Aβ42 fibrils with an EC50 of 10.2 μM. Finally, we confirmed that 3j is also effective at preventing neurotoxicity induced by Aβ42-oligomers as well as Aβ42-fibrils.

This paper emphasizes the importance of robot's ability to refer its task history, when it executes a series of pickand-place manipulations by following text instructions given one by one. The advantage of referring the manipulation history can be categorized into two folds: (1) the instructions omitting details or using co-referential expressions can be interpreted, and (2) the visual information of objects occluded by previous manipulations can be inferred. For this challenge, we introduce the task of history-dependent manipulation which is to visually ground a series of text instructions for proper manipulations depending on the task history. We also suggest a relevant dataset and a methodology based on the deep neural network, and show that our network trained with a synthetic dataset can be applied to the real world based on images transferred into synthetic-style based on the CycleGAN.