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A system for monitoring blood pressure or other physiological variables in the unanesthetized and chronically instrumented dog is described. An indwelling catheter attaches to a pressure transducer affixed to the underside of a leather shield, which snaps onto a custom-fitted leather vest worn by the dog. The transducer cable ascends vertically through a hollow, flexible, stainless steel tether, which is attached at the lower end to the leather shield and at the upper end to a fluid and electrical swivel. The swivel is attached to an overhead counterbalanced boom assembly, which moves in concert with the dog, maintaining a constant minimal tension on the tether. The boom assembly is attached to a wall plate via a universal joint approximately 7 ft above floor level. Dogs can be maintained comfortably in this system 24 h1day over periods of months, with freedom of posture and movement, including rotational behavior. The system is economical to construct and provides versatile stimulation and recording capability and reliable long-term performance.