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Targeted radiopharmaceuticals, which mainly include beta-emitting radionuclides, allow for selective action and reduction of the total radiation load. The aim of the study was to assess the viability of human epidermoid carcinoma cells A431 at various intervals after exposure to high-energy electrons in the regime of acute and chronic irradiation. To simulate chronic or acute irradiation, cells were irradiated with closed Sr-Y-90 sources (STC, Amplituda) and a Novalis Tx linear accelerator (Varian Medical Systems, UK), respectively. At 24 and 72 hours after the start of irradiation, an MTT test was performed for the subsequent determination of LD50. We registered a difference in the viability of A431 cells 24 and 72 hours after irradiation at the same dose: LD50, estimated 72 hours after irradiation, was 2 times lower than after 24 hours. The observed effect is apparently caused by a pronounced radiation block of mitosis 24 hours after exposure. In addition, 72 hours after irradiation, large numbers of "giant" cells are found, formed from several cells as a result of division attempts. In the case of acute irradiation, the radiosensitivity of A431 cells increases approximately fourfold. Apparently, different types of exposure, at the same dose, cause different levels of oxidative stress, which is suppressed to varying degrees by enzymes and the antioxidant system, which affect the repair systems in the cell, which must be taken into account when forming the dose load for patients undergoing radiotherapy.

Seborrheic keratosis is the most common benign tumor of the epidermis. Rarely the tumor develops in the perineal area and quite rarely is large. For the Leser-Trelat syndrome these tumors is a marker of a malignant disease even before the symptoms are appeared, as well as a manifestation of the paraneoplastic process. In our case report, a giant perianal seborrheic keratoma was the reason for the clinical examination of the patient and stomach cancer was detected. As a result, we demonstrated a successful experience of surgical treatment of seborrheic keratoma of the perianal area and determined an algorithm for the treatment of stomach cancer.

Proposals for the change of criminal procedure law for the use of mediation in the preliminary investigation are formulated in the article. Mediation can replace the long pre-trial proceedings. Execution of a mediation agreement conditions will be a major challenge for law enforcement. This proposal would not establish the subject of evidence in every criminal case.