Single IUI timed post-ovulation gives a better CPR when compared with single pre-ovulation IUI for non-male infertility, whereas for male factors, pre-ovulation, double IUI gives a better CPR when compared with single IUI.

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AH, Hill MJ. Progesterone luteal support after ovulation induction and intrauterine insemination: an updated systemic review and meta-analysis. Fertil Steril 2017 Apr;107(4):924-933.

number of fair to good quality blastocysts and utilization rates of blastocysts. This study is unique from prior studies in that 96.4% of study patients underwent antagonist stimulation cycles with GnRH agonist trigger.DESIGN: Prospective cohort study. MATERIALS AND METHODS: All patients underwent IVF / ICSI between August 2016 and February 2017 at a tertiary academic fertility centre. All patients included were normal responders with > 8 mature follicles (> 17 mm) at retrieval. All patients were assigned to alternate ovarian (left or right) flushing on an alternating day allocation. Each patient was used as their own control comparing the ovary with the aspirated and flushed follicles to the contralateral ovary with follicles which were retrieved using standard aspiration without flushing. Because of this study design, statistical analysis was carried out using paired T-tests for comparison of flushed and non-flushed ovaries.RESULTS: 111 patients were included with no statistical difference in any outcome if either the left or right ovary was allocated to be flushed. The mean number of oocytes retrieved from the flushed ovary was 9.5 compared to 8.8 in the unflushed ovary (P ¼ 0.13). Mean mature (M2) oocytes retrieved was 7.5 from the flushed ovary, compared to 6.9 from the unflushed ovary (P ¼ 0.12). Blastocysts of good quality obtained from the flushed and unflushed ovaries were 2.5 and 2.1 (P ¼ 0.17). Blastocyst utilization rates from the flushed and unflushed ovaries were 56% and 51% (P ¼ 0.17).CONCLUSIONS: All outcomes studied showed no statistically significant difference between the flushed and unflushed ovary. This is concordant with published studies showing no difference with follicular flushing. This study adds to the literature as uniquely 96.4% of IVF / ICSI cycles included had used GnRH antagonist stimulation and GnRH agonist trigger. This study suggests that follicular flushing does not provide any clinical benefits in patients who are good responders when using an antagonist stimulation cycle with GnRH agonist trigger.