Background: The 2019 Coronavirus disease (COVID-19) has caused a global distress. However, its psychological impact on patients is unclear. We aim to determine the mental health status and explore related factors of anxiety and depression among patients with . Methods and main outcome measures: This is a cross-sectional descriptive survey conducted among COVID-19 patients at the Mohammed VI University Hospital Centre in Marrakech over a period of four months. We assessed symptoms of depression and anxiety using the Arabic version of the Hospital Anxiety and Depression Scale (HADS) on admission. The significance threshold used for any data comparison test was the value of p < 0.05. Results: A total of 103 participants were included. The average age was 44, 17 ± 17, 19 years. About 54,4% of the subjects were male. Of the 103 participants, 36.89% and 23.30% patients with COVID-19 had symptoms of anxiety or depression; respectively. The mean score of anxiety subscale and depression subscale for all patients was 6.45 ± 4.29 and 5.38 ± 4.47, respectively. The bivariate analysis showed that age (p=0, 0004; p=0, 0002), oxygen saturation level (p=0, 0003; p=0, 0059), hospital stay (p <0, 0001; p <0, 0001) and family infection with SARS-CoV-2 (p=0, 0094; p=0, 0023) were associated with anxiety and depression respectively for COVID-19 patients. Moreover, gender (p=0, 0119) was associated with depression. Conclusion:There is an increasing level of anxiety and depression in hospitalized patients with COVID-19. Mental concern and appropriate intervention remain an important part of clinical care for those who are at risk.

Infection with the new coronavirus has been declared an international health emergency. Its curative treatment is unknown and is the subject of several clinical trials. In addition, the concomitant association of COVID-19 with tuberculosis and the human immunodeficiency virus, hitherto never described, is potentially fatal. We report the illustrative case of a 32-year-old patient who presented this trifecta of infections and who did well under treatment with chloroquine and anti-mycobacterial drugs. This patient arrived at the ER with respiratory discomfort that had been evolving over a month with symptoms of flu and deterioration of her general condition. A chest CT scan revealed an aspect of lung miliary tuberculosis with isolation of Koch’s bacilli in the sputum. A polymerization chain reaction (PCR) was positive for COVID-19 on a nasopharyngeal swab. HIV serology was positive. The course was marked by a spectacular clinical improvement and two negative COVID-19 PCR controls at the end of treatment (at days 9 and 10). Anti-tubercular drugs (especially, rifampin) are powerful enzyme inducers that can reduce the effectiveness of chloroquine in our patient. This therapeutic success may be linked to the effect of anti-tubercular drugs against SARS ncov-2, especially rifampin, inhibiting the formation of messenger RNAs of SARS ncov-2 or to the synergistic effect of chloroquine and rifampin. Researchers should explore the effect of these drugs on SARS ncov-2.

La tuberculose ganglionnaire (TG) est la localisation extrapulmonaire la plus fréquente au Maroc. Elle pose encore un problème diagnostique et thérapeutique. Le but du travail est d’ étudier le profil épidémiologique, diagnostique et thérapeutique de la tuberculose ganglionnaire. Il s'agit d'une étude rétrospective portant sur les nouveaux cas de TG suivis au centre spécialisé de tuberculose de Marrakech, entre Janvier 2011 et Décembre 2012. Trois cents cinquante sept cas de TG ont été inclus sur l'ensemble de 1717 cas de tuberculose toute forme confondue, soit une incidence de 20,8%. La moyenne d’âge était de 29,1 ans avec un sex ratio de 0,6 (62,5% de femmes). Le diabète, le contage tuberculeux et l'infection VIH ont été retrouvés respectivement dans 9%, 14,6% et 3,6% des cas. Les adénopathies étaient cervicales dans 95%, médiastinales dans 5,1%, abdominales dans 3,7%, axillaires dans 2,8% et inguinales dans 0,3% des cas. La radiographie du thorax (faite dans 96,4% des cas) a été anormale dans 8,1%. Le diagnostic a été confirmé dans 97,2% des cas. Le régime thérapeutique était 2 RHZE/4RH dans 88% des cas. Dans les cas suivis, l’évolution a été marquée par la disparition des adénopathies dans 95,2% et par l'augmentation du volume ganglionnaire dans 4,8%. 1,4% des cas ont été perdus de vue. La rechute de TG a été notée dans 3,1%. La TG reste fréquente et occupe la 2ème place après l'atteinte pulmonaire et pose un problème diagnostique et thérapeutique.

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Introduction: The lung adenocarcinoma is an invasive malignant tumor. Its visceral metastases are multiple. The gingival location is uncommon if not exceptional. Observation: We report the case of 66-year-old patient with a right cervical radiculopathology. Clinical examination objectified a superior vena cava syndrome with gingival tumor budding whose excisional biopsy found a location of a poorly differentiated and infiltrating carcinoma. The bronchoscopy revealed a tumor nodule obstructing the right mainstem bronchus with the histological study concluded as a moderately differentiated adenocarcinoma infiltrating. Conclusion: Gingival metastasis revealing lung adenocarcinoma is uncommon even exceptional. It may delay the diagnosis and management of already poor prognosis.