Post-laparoseopy pain can increase recovery time and delay patient discharge. While previous studies have focused on the problems of nausea and vomiting, the purpose of this study was to assess the effect of diclofenac (a non-steroidal antiinflammatory drug) Krisfianstad County Council provided financial support. Ciba-Geigy, Sweden, supplied the diclofenac and placebo used in this study.Accepted for publication 5th January, 1993.
Le diclofdnac produit un meilleur soulagement it 24 hres (1,0 vs 2,5, P < 0,05) et diminue le nombre de patientes qui ont besoin d'analgdsiques additionnels (7 vs 15, P < 0,05). 17 n'y a pas de difference dans Hncidence des effets secondaires. Ces donn~es suggbrent que le diclofdnac diminue la douleur postlaparoscopie et les besoins postop~ratoires d'analg~siques.In many patients post-laparoscopy pain is severe and difficult to manage. ~ In a recent study, peritoneal biopsy, performed two or three days after laparoscopy, showed peritoneal inflammation resulting from capillaries which were torn at the time that the abdomen was distended with gas. In the same study a linear relationship was found between abdominal compliance at the time of laparoscopy and the severity of postoperative pain. 2 Postoperative pain control using non-steroidal antiinflammatory drugs (NSAIDs) may reduce peritoneal inflammation and consequently reduce the pain. The purpose of this study was to assess the analgesic efficacy of rectally administered diclofenac before surgery on postoperative pain following gynaecological laparoscopy.
MethodsAfter approval of the protocol by the Ethical Committee of the Faculty of Medicine of the University of Lund, informed written consent was obtained from 49 women, ASA I-II, who required laparoscopic surgery. If laparotomy was performed, the patient was excluded from the study. Each patient was allocated to one of the study groups according to a random number sequence.
ProcedureAll patients underwent laparoscopy with general anaesthesia. Sixty minutes before induction of anaesthesia meperidine 75 mg (Petidin, Kabi, Sweden) was given On. At the same time diclofenac sodium 50 mg (Voltaren/ Voltarol, Ciba-Geigy, Basle) or placebo was administered pr to the patient in a randomized double-blind manner. The ECG monitored continuously. After glycopyrrolate 3 ~g" kg -I (Robinul, Robins, UK) anaesthesia was induced with fentanyl, 1 ~tg. kg -I (Leptanal, Janssen Pharmaceutica, Belgium), followed by thiopentone, 4-5 mg. kg -1 (Pentothal, Abbot, US). Tracheal intubation CAN J ANAESTH 1993 / 40:5 / pp406--8
