Objective To examine the distribution of mast cells in human uterine tissue and to study the interactions between mast cell mediators (histamine and serotonin) and PGF,, in human myometrium contractile activity.Design Distribution of mast cells were analysed in cryostat sections of myometrium samples stained with Toluidine blue. Contractile activity was evaluated in an isolated organ bath preparation on myometrial strips obtained from women whose pregnancies ended in elective caesarean section.Setting Biological Science Laboratories at the University of Concepci6n.Subjects Twenty women undergoing elective caesarean and 10 women undergoing hysterectomy at the G. Grant Hospital.Main outcome measurements Cumulative concentration-response curves for histamine and serotonin before and after the addition of subumbral concentrations of the PGF,, or serotonin were performed.

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