Metallothionein mRNA expression is altered significantly in oral squamous cell carcinomas. The expression of MT1G, MT1X and MT3 may aid in the prognostic discrimination of OSCC cases.

To report a case with advanced IHCC treated with chemoembilization as an alternative method. Case report: A 50 y.o. female presented with epigastric pain, anicteric, an with an epigastric palpable mass extending to the hight upper quadrant, slightly painful. Abdominal Ultrassound and upper digestive endoscopy revealed a large liver bulky mass with extrinsic compression of the anterior wall of the stomach. CT scan and MR exams suggested an IHCC. Tumours markers were negative. A diagnostic laparoscopy was performed and confirmed a large mass occupying the entire left hepatic lobe and invading right lobe, with intrahepatic metastatic nodules near main tumor. Biopsy was performed showing a moderate differentiated IHCC. A drug-eluding bead trascatheter arterial chemoembolization was performed and the patient is well with no complications after 32weeks of the procedure. Discussion: Surgery is the main treatment for IHCC because is the only option with curative potential. However, in advanced stages of the disease, surgery can be controversial due to the high morbility and risk of complication. There is no evidence that chemoterapy is a good alternative and chemoembolization seems to be the best choice of treatment in these cases, with about 50% of response rate with 12e15 months of survival, comparing with 3.3 months with chemotherapy. Conclusion: Chemoembolization seems to be the best alternative for advanced IHCC, with better survival and lower rates of complications than other treatments.

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