The electronic scientific and practical journal is registered in international scientometric data bases, repositories and search engines. The main characteristic of the edition is the index of scientometric data bases, which reflects the importance and effectiveness of scientific publications using indicators such as quotation index, h-index and factor impact (the number of quotations within two years after publishing).In 2020,
The regioselectivity of the reaction of 2-chloro- and 2,3-dichloro-5-substituted naphthoquinones with CH-acids is studied. It is shown that the nature of the substituent in 5-RO-1,4-naphthoquinones plays the main role in the predominant formation of one of the possible regioisomers in the reactions of nucleophilic substitution. It is substantiated that the orientation of the nucleophilic attack by CH-acid on the C3 atom of 5-RO-1,4-naphthoquinones is due to the fact that the 5-methoxy and 5-acetoxy groups have a passivating effect on the electron-accepting properties of the C4=O group due to the positive conjugation effect. As a result, the electrophilic center appears in position 3. It is established that the interaction of 2- or 3-chloro-substituted 5-RO-1,4-naphthoquinones with CH-acids proceeds with the formation of 2- and 3-addition products with a preference for products of substitution of the chlorine atom in 3rd position. The structure of the regioisomers is confirmed by spectral data and by countersynthesis.
Antiviral activity was predicted by using data from program PASS Online for synthesized compounds against picornavirus, the influenza and the rhinovirus, what fits in today's strategy of creating of the anthraquinone-based anticancer drugs and with antibacterial effect. There are several current methods to synthesize 9,10-anthraquinone, which contain the biogenic amines in the 4-position. Antiviral activity was predicted by using program AVCpred in a percentage of inhibition against deadly viruses like Human immunodeficiency virus (HIV), Hepatitis C virus (HCV), Hepatitis B virus (HBV), Human herpesvirus (HHV)
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