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We present retrospectively our experience in the use of high-dose chemotherapy and haematopoietic stem cell support (HSCS) for refractory gestational trophoblastic neoplasia (GTN) Occasional patients with gestational trophoblastic neoplasia (GTN) will have an incomplete response to conventional chemotherapy or will relapse from remission. There have been several case reports of high-dose chemotherapy (HDC) and haematopoietic stem cell support (HSCS) in patients with refractory GTN (Collins et al, 1991;Giacalone et al, 1995;Lotz et al, 1995;Nagatoshi et al, 1996;Chou et al, 1997;van Besien et al, 1997;Aoki et al, 1999;Knox et al, 2002). The results have been mixed and no clear prognostic scoring system has been developed to identify which patients may benefit from HDC. MATERIALS AND METHODSIn all, 11 patients with refractory or relapsing GTN were treated with HDC and HSCS at three supraregional trophoblast centres (Charing Cross Hospital, London, UK, Weston Park Hospital, Sheffield, UK and Waikato Hospital, New Zealand)

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