Alcohols Alcohols Q 0230Enantioselective Synthesis of 1-Alkyl-Substituted 1-Phenyl-1,2-ethanediols Using a Myrtenal-Derived Chiral Auxiliary. -An efficient enantioselective synthesis of title phenylethanediols is presented, involving a myrtenal-derived chiral auxiliary in the nucleophilic addition of Grignard reagents or organolithiums (IV) towards an optically pure benzoyloxathiane (III). Most of the addition reactions proceed with excellent diastereoselectivity. Hydrolytic cleavage of the O,S-acetals (V) followed by reduction of the evolving phenylacetaldehyde then affords the optically active 1,2-diols (VI), (VII) in excellent stereoselectivity. Additionally, optimum conditions are identified for the highly diastereoselective reduction of benzoyloxathiane (III). -(VARGAS-DIAZ, M. E.; CHACON-GARCIA, L.; VELAZQUEZ, P.; TAMARIZ, J.; JOSEPH-NATHAN, P.; ZEPEDA*, L. G.; Tetrahedron:

Imidazole derivatives R 0190Parallel and Automated Library Synthesis of 2-Long Alkyl Chain Benzoazoles and Azole[4,5-b]pyridines under Microwave Irradiation. -A 40-membered library of pharmacologically interesting anellated imidazoles and oxazoles (III), (V) and (VII) is prepared. In addition, derivatives with long alkyl chains may be useful as corrosion inhibitors for oil field applications. -(MARTINEZ-PALOU*, R.; ZEPEDA, L. G.; HOEPFL, H.; MONTOYA, A.; GUZMAN-LUCERO, D. J.; GUZMAN, J.; Mol. Diversity 9 (2005) 4, 361-369; Inst. Mex. Pet., Gerencia Catal. Mat., Eje Cent. Lazaro Cardenas, 07730 Mexico, Mex.; Eng.) -Nuesgen 21-130

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.