Background Self-injurious behaviour (SIB) is a relatively common problem for people

We describe the coupling of a microfabricated fluidic device to an electrospray ionization (ESI) quadrupole time-of-flight mass spectrometer (QqTOFMS) for the identification of protein samples. The microfabricated devices consisted of three reservoirs connected via channels to a main capillary, which in turn was linked via a microspray interface to the QqTOFMS. Here we present preliminary results obtained using this system. Standardized solutions of myoglobin tryptic digest were analyzed indicating a limit of detection at the low to sub fmol/microL. The combination of the microfabricated device for rapid sample delivery and the rapid acquisition capability, enhanced resolution and mass accuracy of the QqTOF offers unique possibilities for the rapid identification of proteins by database searching. This platform can generate MS data suitable for protein database searching by the peptide-mass fingerprinting approach and MS/MS data suitable for protein database searching. Here the results of the two database-searching approaches are compared and the possibilities of combining the two approaches for rapid identification of protein are discussed. Also, we present a comparison of the results obtained using the three-position microfabricated device coupled to the ESI-QqTOFMS and to an ESI-ion trap MS. Finally the combination of C-terminal 18O labeling of peptides and the microfabricated system for automated combined peptide-mass fingerprinting and sequence-tag database searching is discussed.

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There has been some question as to what the Peabody Picture Vocabulary Test measures. Although research indicates it has inadequate validity as a test of intelligence, other studies indicate it is an adequate measure of language ability. The present study correlated and factor analyzed the results from the Peabody test with results from a measure of linguistic and intellectual functioning. The analysis indicates that the test is not an adequate measure of either linguistic or intellectual abilities.

Children from four isolated coastal communities in Labrador were given a series of standardized tests. Of particular interest in the findings are the differential psycholinguistic profiles of the subjects. These results offer support for the claim that ecological demands to some extent determine cognitive structures. The results also indicate that the subjects have abilities in a number of areas that are within one standard deviation of the mean for the normative sample. These suggest areas that could be capitalized upon in order to make the educational system more meaningful to these children.